Tag: mTOR

Rapamycin for COVID-19 by Mikhail V. Blagosklonny

Section 11 from forthcoming review entitled “From causes of aging to death from COVID-19” (read full review soon) As soon as COVID-19 epidemic started, it become clear that COVID-19 vulnerability is aging-dependent condition and the use of rapamycin (Sirolimus) was immediately suggested by independent researches {Sargiacomo, 2020 #9}, {Zhavoronkov, 2020 #105}, {Zhou, 2020 #94}{Omarjee, 2020 … Continue Reading

How rapamycin prevents muscle loss and sarcopenia (first draft)

The effect of rapamycin, an anti-aging drug, on the muscle, was puzzling for a decade. It seemed paradoxical that rapamycin, an inhibitor of mTOR component 1 (mTORC1), prevents muscle loss and sarcopenia. Yet, this is well established [1-5]. How is that possibly possible?  The nutrient-sensing mTOR pathway increases protein synthesis and cellular mass growth. Furthermore, … Continue Reading

Rapamycin: time is now … unless it’s too late

In 2006, I published an article that aging is not caused by free radicals nor by any kind of molecule damage but instead is a quasi-program driven in part by mTOR (Target of Rapamycin). By sheer luck, mTOR inhibitors – Sirolimus (rapamycin) and Everolimus – were clinically available. As I summarized in 2006: “…all diseases of aging … Continue Reading